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Personalized Pain Management Diagnostic
This technology evaluated more than 70 relevant SNPs for their clinical utility in determining inter-individual variability in response to a dose of morphine and opioids. By confirming many of the previous genotype-phenotype associations reported in literature, our researchers have found several strong novel associations with clinical outcome measures,...
Published: 10/18/2023
Category(s): Diagnostics
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SapC-DOPS Agents in Imaging Arthritis
(CHMC Ref. Id: 2011-0503)
Overview:
Rheumatoid arthritis (RA) is a chronic inflammatory disease
that affects about 1% of the population and is characterized by the destruction
of cartilage and bone ultimately leading to loss of joint function. To date,
reliable and non-invasive techniques that accurately measure arthritic disease
onset and progression...
Published: 8/7/2018
Category(s): Diagnostics
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Simultaneous ASL/BOLD Functional MRI
This technology can provide a fundamental building block for studies of functional neuropathology in subjects using functional MR methods. Abnormalities in the neural substrates of attention, language, and memory may be better understood against the backdrop of normal age-dependent trends. Arterial spin labeling (ASL) functional imaging provides...
Published: 10/10/2019
Category(s): Diagnostics
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Diagnostic for Progression of Fatty Liver Disease
Diagnostic for Progression of
Fatty Liver Disease
(CHMC Ref. Id: 2009-1204)
Overview:
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease worldwide today. However, there is currently no widely validated
and reliable non-invasive biomarker for fibrosis progression in non-alcoholic
steatohepatitis (NASH), the...
Published: 5/14/2024
Category(s): Diagnostics
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IL-13 Induced Gene Signature for Eosinophilic Esophagitis
IL-13 Induced Gene Signature
for Eosinophilic Esophagitis
(CHMC Ref. Id: 2007-0811)
Overview:
Eosinophilic esophagitis (EE) is an emerging worldwide disease. The
current treatment for EE is with swallowed glucocorticoids, however, only a
subset of EE patients experience remission from the disease following treatment
with topical steroids. Dr....
Published: 8/20/2018
Category(s): Diagnostics
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Lupus Nephritis Diagnostic Biomarker Panel
Four renal biomarkers: transferrin (TF), ceruloplasmin (Cp), lipocalin-type prostaglandin-D synthetase (L-PGDS), and alpha-1-acid glycoprotein (AGP), are capable of accurately diagnosing and determining the course of LN in both children and adults with systemic lupus erythematosis (SLE). While each individual biomarker can be used alone, the combination...
Published: 9/11/2022
Category(s): Diagnostics
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Serum Biomarker for Stratifying Patients in Septic Shock Clinical Trials
Overview:
Currently,
there exists no method for stratifying pediatric septic shock clinical trial
candidates. Specifically, there is no way to eliminate patients that would have
a high likelihood of a positive outcome with standard care from these trials.
Dr. Wong at Cincinnati Children's Hospital has demonstrated that there is a
marked increase...
Published: 8/20/2018
Category(s): Diagnostics
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Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis
Diagnostic and Prognostic for
Crohn's Disease and Ulcerative Colitis
(CHMC Ref. Id: 2007-0105)
Overview:
Several defects in neutrophil function have been noted in Crohn's Disease
(CD), including reduced phagocytosis, adhesion, chemotaxis, and oxidative burst.
This has been shown to reduce neutrophil accumulation at sites of injury,
promoting...
Published: 10/31/2023
Category(s): Diagnostics
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Diagnostic and Prognostic for Crohn's Disease
Diagnostic and Prognostic for
Crohn's Disease
(CHMC Ref. Id: 2006-0202)
Overview:
Standard therapies for IBD include steroids and immunomodulators which lead
to a sustained remission in approximately 50% of patients. Currently, there are
no reliable predictors of response, leading Dr. Denson and colleagues to prepare
and stratify patient...
Published: 2/8/2023
Category(s): Diagnostics
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Expression Profile for Acute Childhood Asthma
Asthma is the most common chronic disease of childhood and has a strong genetic component. This technology identifies gene expression signatures that differentiate stable asthma and acute exacerbations. Researchers profiled gene expression patterns in nasal respiratory epithelial cells from children who had stable asthma, those experiencing asthma exacerbation,...
Published: 6/28/2022
Category(s): Diagnostics
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